Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats.
Identifieur interne : 000005 ( Main/Exploration ); précédent : 000004; suivant : 000006Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats.
Auteurs : Yingshou Xing [République populaire de Chine] ; Yi Qin [République populaire de Chine] ; Wei Jing [République populaire de Chine] ; Yunxiang Zhang [République populaire de Chine] ; Yanran Wang [République populaire de Chine] ; Daqing Guo [République populaire de Chine] ; Yang Xia [République populaire de Chine] ; Dezhong Yao [République populaire de Chine]Source :
- Cognitive neurodynamics [ 1871-4080 ] ; 2016.
Abstract
Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.
DOI: 10.1007/s11571-015-9361-1
PubMed: 26834859
Affiliations:
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Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Yao, Dezhong" sort="Yao, Dezhong" uniqKey="Yao D" first="Dezhong" last="Yao">Dezhong Yao</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; 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Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Yang" sort="Xia, Yang" uniqKey="Xia Y" first="Yang" last="Xia">Yang Xia</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Yao, Dezhong" sort="Yao, Dezhong" uniqKey="Yao D" first="Dezhong" last="Yao">Dezhong Yao</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cognitive neurodynamics</title><idno type="ISSN">1871-4080</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xing, Yingshou" sort="Xing, Yingshou" uniqKey="Xing Y" first="Yingshou" last="Xing">Yingshou Xing</name></noRegion><name sortKey="Guo, Daqing" sort="Guo, Daqing" uniqKey="Guo D" first="Daqing" last="Guo">Daqing Guo</name><name sortKey="Jing, Wei" sort="Jing, Wei" uniqKey="Jing W" first="Wei" last="Jing">Wei Jing</name><name sortKey="Qin, Yi" sort="Qin, Yi" uniqKey="Qin Y" first="Yi" last="Qin">Yi Qin</name><name sortKey="Wang, Yanran" sort="Wang, Yanran" uniqKey="Wang Y" first="Yanran" last="Wang">Yanran Wang</name><name sortKey="Xia, Yang" sort="Xia, Yang" uniqKey="Xia Y" first="Yang" last="Xia">Yang Xia</name><name sortKey="Yao, Dezhong" sort="Yao, Dezhong" uniqKey="Yao D" first="Dezhong" last="Yao">Dezhong Yao</name><name sortKey="Zhang, Yunxiang" sort="Zhang, Yunxiang" uniqKey="Zhang Y" first="Yunxiang" last="Zhang">Yunxiang Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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